Steroid modified oligonucleotides

Details Steroid modified oligonucleotides Steroid modified oligonucleotides

1993-07-26

1995-05-16

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 5, 536 2531, 536 2533, C07H 2100

Patent

active

054162033

ABSTRACT:
An oligonucleotide conjugated to a steroid the oligonucleotide comprising: ##STR1## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; B is a naturally occurring base, the steroid is bound to the oligonucleotide utilizing the naturally occurring bases through an (-oxycarbonyl-amino)-decylamine-moiety, and NUC is an oligonucleotide.

REFERENCES:
patent: 4958013 (1990-09-01), Letsinger
Letsinger et al., Proc. Natl. Acad. Sci, USA, vol. 86, pp. 6553-6556, Sep. 1989.

Affiliated with

Also associated with

Rating

Steroid modified oligonucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Steroid modified oligonucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Steroid modified oligonucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-638691