Steroid hormone products and methods for preparing them

Details Steroid hormone products and methods for preparing them Steroid hormone products and methods for preparing them

2011-01-11

2011-01-11

Qazi, Sabiha (Department: 1612)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C552S515000, C552S516000

Reexamination Certificate

active

07867990

ABSTRACT:
The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to methods for making such steroid hormone products, wherein a mixture of the hormone and the excipient is subjected to sufficient mechanical energy to form a powder blend wherein the hormone is stabilized by the excipient in substantially non-crystalline form.

REFERENCES:
patent: 2636042 (1953-04-01), Salkin
patent: 2642427 (1953-06-01), Hasbrouck
patent: 2648700 (1953-08-01), Jacobsen et al.
patent: 2666066 (1954-01-01), Hasbrouck
patent: 3032469 (1962-05-01), Gleason
patent: 3691212 (1972-09-01), Feather et al.
patent: 4046874 (1977-09-01), Gabby et al.
patent: 4544554 (1985-10-01), Pasquale
patent: 4785103 (1988-11-01), Shibata et al.
patent: 5266712 (1993-11-01), Lanquetin
patent: 5342627 (1994-08-01), Chopra et al.
patent: 5382434 (1995-01-01), de Haan et al.
patent: 5407928 (1995-04-01), Kasch et al.
patent: 5527543 (1996-06-01), Dopper et al.
patent: 5633242 (1997-05-01), Oettel et al.
patent: 5720977 (1998-02-01), Deghenghi
patent: 5858405 (1999-01-01), Gast
patent: 6290991 (2001-09-01), Roser et al.
patent: 6495532 (2002-12-01), Bathurst et al.
patent: 6902741 (2005-06-01), Grawe et al.
patent: 0503521 (1992-09-01), None
patent: 0587047 (1994-03-01), None
patent: 0657161 (1995-06-01), None
patent: WO 97/04750 (1997-02-01), None
patent: 9804269 (1998-02-01), None
Nelson et al. (AN 74012246, Medline, J. of the National Cancer Institute, (1973), 51(4), 1303-11).
Merck Index, 12th Edition, 1996, p. 632 (3751).
Estrogens, Steroidal. Substance profiles: Report on Carcinogens, Eleventh Edition, 2002.
Buckton et al.; “The influence of additives on the recrystallisation of amorphous spray dried lactose”; International Journal of Pharmaceutics, 121 (1995), pp. 81-87.
Huttenrauch et al.; “Mechanical Activation of Pharmaceutical Systems”, Pharmaceutical Research 1985, pp. 302-306.
Lieberman et al.; “Pharmaceutical Dosage Forms”, Marcel Dekker, Inc., vol. 2 (1990), pp. 213-217 and 327-329.
Morita et al.; “Physicochemical Properties of Crystalline Lactose. II1. Effect of crystallinity on Mechanical and Structural Properties.”, Chem. Pharm. Bull., 32(10) 1984, pp. 4076-4083.
Sebhatu et al.; “Assessment of the degree of disorder in crystaline solids by isothermal microcalorimetry”, International Journal of Pharmaceutics 104 (1994), pp. 135-144.
Jain, et al.: “Stability of a hydrophobic drug in presence of hydrous and anhydrous lactose”. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier Science Publishers B.V., Amsterdam, NL., vol. 46, No. 2, Sep. 1998, pp. 177-182, XP004257039, ISSN: 0939-6411.

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