Steroid hormone-antitumor derivatives

Details Steroid hormone-antitumor derivatives Steroid hormone-antitumor derivatives

1980-12-02

1982-11-23

Roberts, Elbert L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

2603975, C07J 1700, C07J 300

Patent

active

043606636

ABSTRACT:
A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of ##STR2##

REFERENCES:
patent: 4242332 (1980-12-01), Albrecht et al.

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