Steroid esters useful against skin disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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552636, A61K 3156

Patent

active

060253479

ABSTRACT:
Novel steroid esters useful for regulating skin atrophy, and skin maladies, as well as compositions containing the esters and methods for their use are described. A preferred steroid ester is DHEA salicylate. Such types of skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells. Such skin maladies include but are not limited to dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritis, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

REFERENCES:
patent: 3879537 (1975-04-01), Van Scott et al.
patent: 3920835 (1975-11-01), Van Scott et al.
patent: 3984566 (1976-10-01), Van Scott et al.
patent: 3988470 (1976-10-01), Van Scott et al.
patent: 4105782 (1978-08-01), Yu et al.
patent: 4105783 (1978-08-01), Yu et al.
patent: 4194007 (1980-03-01), Van Scott et al.
patent: 4197316 (1980-04-01), Yu et al.
patent: 4234599 (1980-11-01), Van Scott et al.
patent: 4246261 (1981-01-01), Van Scott et al.
patent: 4363815 (1982-12-01), Yu et al.
patent: 4380549 (1983-04-01), Van Scott et al.
patent: 4496556 (1985-01-01), Orentreich
patent: 4542129 (1985-09-01), Orentreich
patent: 4628052 (1986-12-01), Peat
patent: 4898694 (1990-02-01), Schwartz et al.
patent: 4920115 (1990-04-01), Nestler et al.
patent: 4956355 (1990-09-01), Prendergast
patent: 5001119 (1991-03-01), Schwartz et al.
patent: 5028631 (1991-07-01), Schwartz et al.
patent: 5077284 (1991-12-01), Loria et al.
patent: 5091171 (1992-02-01), Yu et al.
patent: 5110810 (1992-05-01), Eich et al.
patent: 5162198 (1992-11-01), Eich et al.
patent: 5206008 (1993-04-01), Loria et al.
patent: 5227907 (1993-07-01), Loria et al.
patent: 5232917 (1993-08-01), Bolger et al.
patent: 5254343 (1993-10-01), Parah et al.
patent: 5262407 (1993-11-01), Leveque et al.
patent: 5387583 (1995-02-01), Loria et al.
patent: 5407684 (1995-04-01), Loria et al.
Solomons, Organic Chemistry, 3rd edition, pp. 794-795, 1984.
Bellmann et al., "In vitro studies on enzymatic cleavage of steroid esters in the female organism" Acta Endocrinologica, vol. 81, pp. 839-853, 1976.
L.G. Wade, Jr. Organic Chemistry 2d Edition, Prentice Hall, Englewood Cliffs, New Jersey (1991).
Bellman, et al. "In Vitro Studies on Enzymatic Cleavage of Steroid Esters in the Female Organism" (1976) Acta Endocrinologica 81, 839-53.
Morrison, M.T. and Boyd, R. N, "Organic Chemistry," Third Edition, Allyn and Bacon, Inc., Boston, 1973.
R.T. Morrison et al., Organic Chemistry 602-603 (3d ed. 1973).
R.T. Morrison et al., Organic Chemistry 672-673 (3d ed. 1973).
Adolf and Swetly, 1979, "Glucocorticoid hormones inhibit DNA synthesis and enhance interferon production in a human lymphoid cell line", Nature 282: 736-738.
Culpepper and Lee, 1987, "Glucocorticoid Regulation of Lymphokine Production by Murine T Lymphocytes", Lymphokines 13:275-289.
Daynes et al., 1990, "Regulation of murine lymphokine production in vivo II. Dehydroepiandrosterone is a natural of interleukin 2 synthesis by helper T cells" European Journal of Immunology 20: 793-802.
Daynes et al., 1990, "Regulation of Murine Lymphokine Production In Vivo; III. The Lymphoid Microenvironment Exerts Regulatory Influences over T Helper Cell Function" J. Experimental Medicine 171: 979-996.
Daynes and Araneo, 1989, "Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4"", European Journal of Immunology 19: 2319-2325.
Lobo et al., 1981, "Dehydroepiandrosterone Sulfate as an Indicator of Adrenal Androgen Function", Obstetrics and Gynecology 57: 69-73.
Loria et al., 1988, "Protection Against Acute Lethal Viral Infections With the Native Steroid Dehydroepiandrosterone (DHEA)", Journal of Medical Virology 26: 301-314.
Loria and Padgett, 1992, "Mobilization of Cutaneous Immunity for Systemic Protection Against Infections", Annals New York Academy of Sciences 650: 363-366.
Orentreich et al., 1984, "Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations thoughout Adulthood", J. Clin. Endocrinol. Metab. 59(3): 551.
Regelson et al., 1988, "Hormonal Intervention: `Buffer Hormones` or `State Dependency` The Role of Dehydroepiandrosterone (DHEA), Thyroid Hormone, Estrogen and Hypophysectomy in Aging", Annals of the New York Academy of Sciences 521: 260-73.

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