Steroid esters of N-(2-halogenethyl)-N-nitroso-carbamoylamino an

Details Steroid esters of N-(2-halogenethyl)-N-nitroso-carbamoylamino an Steroid esters of N-(2-halogenethyl)-N-nitroso-carbamoylamino an

1985-05-08

1986-10-07

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 100

Patent

active

046158359

ABSTRACT:
Steroid-N-(2-halogen ethyl)-N-nitroso-carbamoylamino acid or peptide esters of the general formula: ##STR1## where R.sub.1 and R.sub.2, which may be identical or different, mean the radical of an amino acid beyond the C atom in the beta position (if present), R.sub.3 means the radical of a steroid or a stilbene derivative pharmacologically similar in action, n is a number from 0-5 and Hal stands for chlorine or fluorine, as well as the method for preparing them by the conversion of an appropriate carbamoyl-amino acid or carbamoyl-peptide in a manner known per se with steroid alcohols or the conversion of steroid-amino acid or steroid-peptide esters with corresponding N-nitroso-carbamoylation or corresponding N-nitroso-carbamoyl-amino acids or peptides in a manner known per se.

REFERENCES:
patent: 4177269 (1979-12-01), Fex et al.
patent: 4181669 (1980-01-01), Hansen et al.

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