Steroid ester, and cosmetics and ointments containing the same

Details Steroid ester, and cosmetics and ointments containing the same Steroid ester, and cosmetics and ointments containing the same

1981-05-21

1983-07-12

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

424 63, 424 64, 424DIG5, 424238, 2603972, A61K 742, A61K 702, A61K 7025

Patent

active

043930441

ABSTRACT:
Steroid ester is formed by the reaction between a carboxylic component and cholesterol or methylsterol having two methyl groups attached to the 4-position of the sterol skeleton. The carboxylic component is an .alpha.-branched carboxylic acid having a general formula: ##STR1## (where R.sup.1 is an alkyl group having at least two carbon atoms, and R.sup.2 is an alkyl group having at least four carbon atoms) or a reactive derivative of said .alpha.-branched carboxylic acid. The steroid ester is high in resistance to hydrolysis, exhibits an excellent water-embracing property and, thus, provides an effective oil phase material or base material of cosmetics or ointments.

REFERENCES:
patent: 4309448 (1982-01-01), Takaishi et al.
Gibson et al., "Journal of Physical Chemistry" vol. 77, No. 6 (1973) pp. 837-845.
Cataline et al., "Journal of the American Pharm. Ass." (1944) pp. 107-108.
Fieser et al., "Steroids" (1959) Reinhold Publishing Co. pp. 364-365.

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