Steroid derivatives useful as hypocholesterolemics

Details Steroid derivatives useful as hypocholesterolemics Steroid derivatives useful as hypocholesterolemics

1990-10-16

1991-07-23

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552515, 552516, 552519, 552523, 552537, 552526, 552540, 552544, 540 94, 540120, C07J 900

Patent

active

050345486

ABSTRACT:
Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3.beta.-ol 14.alpha.-methyl-demethylase activity, suppressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol synthesis and reducing serum cholesterol levels are disclosed.

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