Steroid derivatives

Details Steroid derivatives Steroid derivatives

1996-04-12

1997-12-16

Prior, Kimberly J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

C07J 300

Patent

active

056987200

ABSTRACT:
The invented compound ##STR1## is useful for the production of steroidal-17-amides that have 5.alpha.-reductase inhibitory activity.

REFERENCES:
patent: 5302621 (1994-04-01), Kojima et al.
Chemical and Pharmaceutical Bulletin, vol. 33, No. 5, (1985) pp. 2164-2167, "Allylic Rearrangement of Alpha, Beta-Unsaturated Ketone-Diethyl Phosphorocyanidate Adducts".
Dennis A. Holt et al, "Inhibition of Steroid 5.alpha.-Reductase by Unsaturated 3-Carboxysteroids", J. Med. Chem., 33, pp. 943-950 (1990).
Mark A. Levy et al, "Inhibition of Rat Liver Steroid 5.alpha.-Reductase by 2-androstene-3-Carboxylic Acids: Mechanism of Enzyme-Inhibitor Interaction", Biochemistry, 29, pp. 2815-2824 (1990).

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