Steroid cream formulation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai


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514179, 514252, 514399, A61K 906, A61K 3158




A steroid cream formulation which has enhanced physical and chemical stability is formed of (11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy-17-(m ethylthio)androsta-1,4-dien-3-one (tipredane), and a vehicle containing as major ingredients propylene glycol and water together with a sodium citrate or potassium citrate buffer to impart an acid value to the cream formulation of greater than 3, a high melting point wax, such as white wax, to impart proper consistency without adversely affecting stability of the tipredane, benzyl alcohol as a preservative, together with one or more emulsifiers, which include glyceryl stearate, one or more emollients which include isopropyl isostearate or isopropyl palmitate, lubricants and other conventional cream formulation ingredients.

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patent: 4247552 (1981-01-01), Hallesy et al.
patent: 4277475 (1981-07-01), Vickery
patent: 4361559 (1982-11-01), Varma et al.
patent: 4439441 (1984-03-01), Hallesy et al.
patent: 4446145 (1984-05-01), Van Bever
patent: 4636520 (1987-01-01), Umio et al.
patent: 4661493 (1987-04-01), Gibbs
patent: 4782059 (1988-11-01), Gade Busch et al.
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Wojnar et al., 106:78900v, (1986).
Lutsky et al., C.A. 106:78939q, (1985).
Lan et al., C.A. 110:108385h, (1988).


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