Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-12
2005-07-12
Badio, Barbara P. (Department: 1616)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C540S107000
Reexamination Certificate
active
06916921
ABSTRACT:
The present invention relates to steroid compounds of general formula X, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by amino nitrogen bonded to C17of the steroid skeleton via a spacer A.
REFERENCES:
patent: 3342811 (1967-09-01), Sarel et al.
patent: 3419661 (1968-12-01), Elder
patent: 3535312 (1970-10-01), Philippson
patent: 1930473 (1970-12-01), None
patent: 96/00235 (1996-01-01), None
patent: 96/27658 (1996-09-01), None
patent: 97/00884 (1997-01-01), None
patent: 98/28323 (1998-07-01), None
patent: WO 99/58549 (1999-11-01), None
patent: 99/58549 (1999-11-01), None
patent: 99/61010 (1999-12-01), None
patent: 00/50065 (2000-08-01), None
patent: 00/50066 (2000-08-01), None
patent: 00/52142 (2000-09-01), None
patent: 01/19354 (2001-03-01), None
patent: 01/62260 (2001-08-01), None
Mangla et al., “Sterol C-methyl Transferase fromPrototheca wickerhamiiMechanism, Sterol Specificity and Inhibition.” Bioorganic & Medicinal Chemistry, vol. 8, p. 925-936, 2000.
XP-001023708, Sterol C-methyl Transferase fromPrototheca wickerhamiiMechanism, Sterol Specificity and Inhibition, Anil T. Mangla et al., Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409 USA, pp. 926-936, 2000.
XP-002104638, Active Site-directed Inhibitors of Cytochrome P-450, Structural And Mechanistic Implications Of A Side Chain-Substituted Series Of Amino-Steroids, Joel J. Sheets et al., pp. 11446-11452, 1983.
XP-002175968, Inhibition of Cholesterol Side-Chain Cleavage. 4.1Synthesis of A or B Ring Modified Azacholesterols, Matthias C. Lu et al., Journal of Medicinal Chemistry, 1981, vol. 24, No. 9, pp. 1038-1042.
XP-002175969, Steroid Amines. Part V.120-Pyrrolidin-l-ylpregnane Derivatives, M. Davis et al., J.C.S. Perkin I, pp. 1420-1424, 1972.
XP-002175971, Inhibitors of Ergosterol Biosynthesis and Growth of the Trypanosomatid Protozoan Crithidia fasciculata, Mohammad D. Rahman et al., The Journal of Biological Chemistry, vol. 265, No. 9, Issue of Mar. 25, pp. 4989-4996, 1990.
XP-002175972, Steroid Amines. Fungicides Derived from Δ5-3β-Hydroxybisnorcholenic Acid (Fernholz Acid), Hershel L. Herzog et al., H.L. Herzog, C.C. Payne and E. B. Hershberg, vol. 77, pp. 5324-5327, 1955.
XP002216553—Abstract of Japan—Hikim, Amiya P. Sinha: “Effect of 22.25-diazacholesterol dihydrochloride on the spermatogenesis of a wild rat, Bandicota bengalensis”, 1987.
XP002216554—Abstract of Japan—Counsell, R.E. et al.: “Inhibition of cholesterol side-chain cleavage by azacholesterols”, 1971.
XP002216549—Abstract of Japan—Kohan F. et al: “Hypocholesterolemic agents, 9. C-20 Epimeric 22,25-diazacholesterols” J.Med. Chem. (1972), 15(11), 1129-31.
XP002216550—Abstract of Japan—Venton D.L. et al.: “Hypocholesterolemic agents. 10. Synthesis of some model azacholanic acids as potential regulators of steroid biosynthesis and metabolism” J. Med. Chem. (1973), 16(5), 571-3.
XP000982169—Abstract of Japan—Li J-S: “Synthesis And Evaluation Of Pregane Derivatives As Inhibitors Of Human Testicular 17Alpha-Hydroxylase/C17,20-Lyase” Journal of Medicinal Chemistry, American Chemical Society, Washington, U.S., vol. 39, No. 21, 1996, pag4es 4335-4339.
XP002216555—Abstract of Japan—Kabara, Jon J. et al.: “Structure-function activity of azasterols and nitrogen-containing steroids”, 1976.
XP002216558—Abstract of Japan—Chen, Yihui et al.: “Synthesis of several analogs of antifungal steroid alkaloids”, 1998.
XP002216551—Abstract of Japan—Rajeswari, SUndaramoorthi et al.: “A New Synthesis of amides from acyl fluorides and N-silylamines” Tetrahedron Lett. (1987), 28(43), 5099-102.
XP002216552—Abstract of Japan—Xie W et al.: “Structure-activity relationship of aza-steroids as PI-PLC inhibitors” Bioorganic & Medicinal Chemistry, England, May 2001, vol. 9, No. 5, (May 2001), pp. 1073-1083.
Amiya P. Sinha Hikim, “Effect of 22,25-diazacholesterol dihydrochloride on the spermatogenesis of a wild rat, Bandicota bengalensis,” International Journal of Fertility, 1987, pp. 320-323, vol. 32, No. 4, CODEN:INJFA3, ISSN: 0020-725X, University of Calcutta, India, abstract only.
R. E. Counsell et al., “Inhibition of cholesterol side-chain cleavage by azacholesterols,” Biochemical Pharmacology, 1971, pp. 2912-2915, vol. 20, No. 10, CODEN: BCPCA6, ISSN 0006-2952, The University of Michigan, Ann Arbor, MI, abstract only.
F. Kohen et al., “Hypocholesterolemic Agents. 9. C-20 Epimeric 22,25-Diazacholesterols,” 1972, Journal of Medicinal Chemistry, pp. 1129-1131, vol. 15, No. 11, XP-002216549, The University of Michigan, Ann Arbor, MI.
D. L. Venton et al., “Hypocholesterolemic Agents. 10. Synthesis of some model Azacholanic Acids as potential regulators of steroid biosynthesis and metabolism,” Journal of Medicinal Chemistry, 1973, pp. 571-573, vol. 16, No. 5, XP-002216550, The University of Michigan, Ann Arbor, MI.
Blume Thorsten
Esperling Peter
Hegele-Hartung Christa
Badio Barbara P.
Millen White Zelano & Branigan P.C.
Novo Nordisk D/S
Schering AG
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