Steroid compounds having contraceptive and anti-osteoporosis act

Drug – bio-affecting and body treating compositions – Contraceptive

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Details

514169, 514178, 514179, 514182, 552514, A61K 3156, C07J 5300

Patent

active

060778733

ABSTRACT:
The invention relates to a steroid compound having the formula (I) ##STR1## comprising a ring E, said ring sharing carbon atoms at position 16 and 17 with the five-membered ring D and being .alpha. with respect to said D-ring. In addition, the carbon atom at position 17 is substituted with an oxygen atom-comprising group through a CO bond. The invention also relates to a pharmaceutical composition comprising said steroid compound. The steroid compounds of the present invention are very suitable for use in the prevention or treatment of peri-menopausal or menopausal complaints, more preferably the prevention or treatment of osteoporosis. Furthermore, the steroid compounds of the present invention can be used for contraceptive purposes.

REFERENCES:
patent: 5162312 (1992-11-01), Kasch et al.
patent: 5407928 (1995-04-01), Kasch et al.
J. Wang et al., Angewandte Chemie International Edition, 34:16:1749-1752, 1995.

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