Steroid composition

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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A61K 3156

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active

043506909

ABSTRACT:
A steroid pharmaceutical composition for administration as an enema to patients for treatment of inflammatory bowel disorders comprises a liquid suspension of total volume from about 50 to about 150 mls, containing an effective amount in the range of about 0.1 mg to about 2 mg of a steroid drug with high topical activity, such as beclomethasone dipropionate. Administration of such enema compositions to the patient, using such appropriately potent but low doses, has been found to be systemically inactive (presumably due to metabolism by the liver), so that adverse side effects otherwise experienced with such treatment can be avoided.

REFERENCES:
patent: 4013792 (1977-03-01), Eichman
patent: 4225597 (1980-09-01), Finckenor
"Current Therapy" (1979) Article by Korelitz, pp. 391-397.

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