Steriod lotion formulation

Details Steriod lotion formulation Steriod lotion formulation

1987-11-13

1989-09-19

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514180, A61K 3156

Patent

active

048681709

ABSTRACT:
A steroid lotion formulation which has enhanced physical and chemical stability is formed of (11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy-17-(m ethylthio)androsta-1,4-diene-3-one (tipredane), and a vehicle containing as major ingredients polyethylene glycol, propylene glycol and water together with a potassium citrate buffer or tromethamine buffer, and sodium metabisulfite and butylated hydroxytoluene as antioxidants.

REFERENCES:
patent: 2801202 (1957-07-01), Poetsch
patent: 3670080 (1972-06-01), Hirata
patent: 3856954 (1974-12-01), Jackson
patent: 4048310 (1977-09-01), Chen et al.
patent: 4071620 (1978-01-01), Sklar
patent: 4344940 (1982-08-01), Chow et al.
patent: 4436738 (1984-03-01), Bequette et al.
Aldrich Catalog of Fine Chemicals (Aldrich Chemical Company) 1988, p. 1516.

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