Steriod inhibitors of estrone sulfatase and associated pharmaceu

Details Steriod inhibitors of estrone sulfatase and associated pharmaceu Steriod inhibitors of estrone sulfatase and associated pharmaceu

1997-01-29

1998-06-09

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 55, A61K 3158, C07J 7100

Patent

active

057634327

ABSTRACT:
Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) ##STR1## wherein X and Y, or Y and Z, form an oxathiazine dioxide ring or a dihydro-oxathiazine dioxide ring, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat estrogen-dependent disorders are provided as well.

REFERENCES:
patent: 3033860 (1962-05-01), Kuehne
patent: 4297350 (1981-10-01), Babcock et al.

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