Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-02-20
2000-09-05
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A01N 3308
Patent
active
061143960
DESCRIPTION:
BRIEF SUMMARY
This invention relates to a chemical composition suitable for use as a biocide.
A biocide is a composition which is able to destroy microorganisms. These can be divided into two, disinfectants which are agents that are able to destroy the germs of putrifaction or disease or inhibit their action and sterilizers which render objects aseptic, a condition where living pathogenic organisms are absent.
2,4-dichlorobenzyl alcohol is an antimicrobial agent which shows good activity against a wide range of yeasts, moulds dematophytic fungi and bacteria. It is known in the trade as Dybenal and is marketed by Boots PLC as Myacide SP.
2-bromo-2-nitropropan-1,3-diol is a widely used antibacterial agent which may be used as a preservative which is particularly useful as a means of preventing the proliferation of Gram-negative bacteria. It is known in the trade as BRONOPOL and is marketed by Boots PLC under the name of Bronopol-Boots or Myacide BT.
It has been used in a wide range of cosmetics, toiletries pharmaceuticals such as creams gels and ointments and household products such as fabric softeners and liquid detergents disinfectants and cleaners.
Tests have shown that 2-bromo-2-nitropropan-1,3-diol is not adversly affected by commonly used cationic, anionic or non-ionic surfactants.
2-bromo-2-nitropropan-1,3-diol is most stable in acid solution and is preferably used in slightly acidic compositions. It may however be used in neutral and mildly alkaline compositions. It is odour free and a non-irritant and has been shown to retain its activity in the presence of a range of other antimicrobial agents.
2-bromo-2-nitropropan-1,3-diol is bactericidal (causing death of bacteria) in a kill time of 24 hours at 37 C. at concentrations approximately 2-4 fold higher than bacteriostatic levels (inhibiting or retarding growth of bacteria). Tests to determine the bactericidal activity of 2-bromo-2-nitropropan-1,3-diol over short periods of time at room temperature (22 C.) indicate that it is more active against Gram-negative than Gram-positive bacteria. It has only limited activity against yeasts and fungi and hence it is known to use a combination of 2-bromo-2-nitropropan-1,3-diol and 2,4-dichlorobenzyl alcohol.
There is no evidence of antagonism to the action of 2-bromo-2-nitropropan-1,3-diol by 2,4-dichlorobenzyl alcohol and indeed 2-bromo-2-nitropropan-1,3-diol is microbiologically compatible with 2,4-dichlorobenzyl alcohol such that broard spectrum antimicrobial activity may be achieved with a combination of 2,4-dichlorobenzyl alcohol as antifungal agent and 2-bromo-2-nitropropan-1,3-diol as antibacterial agent.
The object of the invention is to provide a rapid acting biocide.
In the present invention there is provided a chemical composition for use as a sterilizer or disinfectant comprising 2-bromo-2-nitropropan-1,3-diol and 2,4-dichlorobenzyl alcohol and characterised in that the composition further comprises a halogen, a halogen compound or a halogenated compound.
In a preferred embodiment the halogen may comprise iodine.
In addition the composition may also comprise one or more surfactants. The or each surfactant may be a cationic, non-ionic, amphoteric or anionic surfactant. Preferably the anionic surfactant sodium lauryl sulphate is used.
The or each surfactant may be utilised in order to solubilise membrane proteins on the organisms thus decreasing the general kill time of the composition. The kill time of the composition can be defined as the time required for 99.9% biocidal action. Surfactants are of particular use when the composition is to be used on organisms having a waxy coat such as for example mycobacterium tuberculosis.
It is preferred that the composition is a water based composition but an alcohol such as 2-propanol (isopropyl alcohol) may additionally be included as a solvent as and when required.
To be a sterilizer the chemical composition must preferably meet the following criteria:-
It must exhibit complete spectrum biocidal action, have a kill time of less than 5 minutes with medically significant vegi
REFERENCES:
patent: 5112515 (1992-05-01), Buxton et al.
Abstract--Derwent Publications Ltd., London, GB, Section CH, Week 8426, AN 84-165127 "Carpet Shampoo Composition Contain Ammonia Ammonium Lauryl Sulphate Bromo Diol Di Chloro Benzyl Alcohol Antistatic Agent Nitro Propane".
Hawley's Chemical Dictionary, 11 Ed., Reinhold Co., NY, 1987, p. 448.
Dees Jos,e G.
Optident International Ltd.
Pryor Alton
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