Sterilization by gamma irradiation

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis

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623 1, 530356, 424423, 424424, 523113, A61F 202

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active

058005420

ABSTRACT:
A method of treating a reconstituted biopolymeric implant which includes the steps of exposing the implant to an aqueous environment so that a final water content of the implant ranges from 5% by weight to a maximal water absorption capacity; and sealing the hydrated implant in a gamma ray-penetrable but bacteria- or virus-impenetrable material. Also disclosed is an implant preparation obtained by the above method.

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Bailey et al., "Irradiation-Induced Crosslinking of Collagen", Radiation Research 22:606-62, 1964.
Cheung et al., "The Effect of .varies.-Irradiation on Collagen Molecules, Isolated .varies.-Chains, and Crosslinked Native Fibers", Journal of Biomedical Materials Research, 24:581-589, 1990.
Li et al., "Gamma-Irradiation of Reconstituted Collagen Matrices With Different Water Contents: Implications in Implantable Device Devel.," The 20th Annual Meeting of the Society for Biomaterials, 1994.
Liu et al., "The Effect of Gamma Irradiation on Injectable Human Amnion Collagen", Journal of Biomedical Research, 23:833-834, 1989.
Urry et al., "Irradiation Crosslinking of the Polytetrapeptide of Elastin and Compounding to Dacron to Produce a Potential Prosthetic . . . ", Journal of Biomedical Materials Research, 16:11-16, 1982.

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