Sterile topical anesthetic gel

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514312, 514535, 514567, 514568, 514617, 514622, 514652, 514653, 514816, 514817, 514818, 514944, A61K 3144, A61K 3147, A61K 3124, A61K 31195

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active

055631533

ABSTRACT:
The present invention provides a topical anesthetic gel composition, comprising: (a) one or more topical anesthetic agents; (b) an adrenergic sympathomimetic compound; and (c) a pharmaceutical gel component. The present invention also provides a topical anesthetic gel composition, comprising: (a) tetracaine HCl, wherein said tetracaine HCl is contained in said composition in an amount of from about 0.01% to about 1.0% by weight, based upon the total weight of said composition; (b) epinephrine HCl topical solution, wherein said epinephrine HCl is contained in said composition in an amount of from about 0.04% to about 0.1% by weight, based upon the total weight of said composition; (c) cocaine HCl, wherein said cocaine HCl is contained in said composition in an amount of from about 3.0% to about 12.0% by weight, based upon the total weight of said composition; and (d) GELFOAM.RTM., wherein said Gelfoam.RTM. is contained in said composition in an amount of from about 6.0% to about 9.0% by weight, based upon the total weight of said composition. Further provided are other topical anesthetic compositions.

REFERENCES:
patent: 4474748 (1984-10-01), Sipos
patent: 4945084 (1990-07-01), Packman
patent: 5192802 (1993-03-01), Rencher
patent: 5196405 (1993-03-01), Packman
Handbook of Nonprescription Drugs, Eight Ed. 1986, pp. 504-505.

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