Sterile pharmaceutical compositions of gadolinium chelates usefu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai

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424 11, 424 4, 424 9, 514 6, 514 79, 514108, 514150, 514184, 534 15, 534 16, C07C22976, C07F 938

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active

049579398

ABSTRACT:
Pharmaceutical compositions comprising gadolinium chelates are useful for enhancing NMR images.

REFERENCES:
patent: 1739840 (0000-01-01), Kendall
patent: 1745134 (1930-01-01), White et al.
patent: 2123929 (1938-07-01), Bousquet
patent: 2196199 (1940-04-01), Dyckerhoff
patent: 2215429 (1940-09-01), Schmidt et al.
patent: 2438876 (1948-03-01), Rieff et al.
patent: 2907789 (1959-10-01), Kreis
patent: 3254103 (1966-05-01), Melby et al.
patent: 3558440 (1971-01-01), Harris et al.
patent: 3567932 (1971-03-01), Alburger
patent: 3661960 (1972-05-01), Carlson
patent: 3663688 (1972-05-01), Grotenhuis
patent: 3700410 (1972-10-01), Sievers
patent: 3758534 (1973-09-01), Popper et al.
patent: 3780079 (1973-12-01), Carlson
patent: 3832457 (1974-08-01), Sugimoto et al.
patent: 3846333 (1974-11-01), Sievers
patent: 3891413 (1975-06-01), Sievers et al.
patent: 3950135 (1976-04-01), Whitesides et al.
patent: 3961932 (1976-06-01), Miller
patent: 3970561 (1976-07-01), Sievers et al.
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4032471 (1977-06-01), Luckey
patent: 4125599 (1978-11-01), Wiegert
patent: 4167564 (1979-09-01), Jensen
patent: 4176173 (1979-11-01), Winchell et al.
patent: 4206132 (1980-06-01), Sievers
patent: 4310507 (1982-01-01), Luckey
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4394353 (1983-07-01), Miyake et al.
patent: 4432907 (1984-02-01), Wieder et al.
patent: 4443380 (1984-04-01), Yamazoe et al.
patent: 4445225 (1984-04-01), White
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4455162 (1984-06-01), Welebir
patent: 4470840 (1984-09-01), Welebir
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4478816 (1984-10-01), Ledley et al.
patent: 4572803 (1986-02-01), Yamazoe et al.
patent: 4615879 (1986-10-01), Runge et al.
patent: 4639365 (1987-01-01), Sherry
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4783330 (1988-11-01), Furie et al.
Elgavish et al., J. Amer. Chem. Soc., 98(16), 4755-4759, (1976).
Dechter et al., J. Magnetic Resonance, 39, 207-215, (1980).
Bryden: Chem. Abstracts 97: 206960z, (1982).
Carmona: Chem. Abstracts 91: 133246k, (1979).
Nozaki: Chem. Abstracts 93: 81186k, (1980).
Fischer, H. W. et al., Contrast Media Research 1989, Sydney and Hamilton Island, Australia, Oct. 8th-13th, 1989.
Oyvin, I. A. et al., "Influence of Phlogodym (Neodymium Pyrocatechol Disulphonate) on the Development of Dextran-Induced Oedema in Normal and Adrenalectomized Rats", Acta Physiologica Academiac Scientiarum Hungaricae, vol. 29(1), pp. 87-90, (1966).
Oyvin, I. A. et al., "Effect of Phlogodym (Neodymium Pyrocatechol Disulphonate on Inflammation Caused by Beta-Rays in the Rabbit", Acta Physiologica Academiae Scientiarum Hungaricae, vol. 29(1), pp. 91-94, (1966).
Carson, A. S. et al., "The Thermodynamics of the Formation of Complexes between Diethylenetriaminepenta-acetic Acid and the Lanthanide Ions", J. Chem. Soc. (A), pp. 1384-1386, (1968).
Oyvin, I. A. et al., "Anticoagulant and Antiphlogistic Properties of Phlogodym (Neodymium Pyrocatechol Disulphonate)", Acta Physiologica Academiae Hungaricae, vol. 24, pp. 373-379, (1964).
Translation of Steidle, "Seltene Erdmetalle," Handbuch der Experimentellen Pharmakologie, pp. 2189-2213, (1935).
Translation of Schubert, "Einige medizinische und biologische Anwendungen von Chelatkomplexen," Chima (Switz.), vol. 11, Fasc. 5, pp. 113-124, (1957).
Translation of Laas et al., "Das Schicksal des Neodymsalzes der 3-Sulfoisonico-tinsaure im Organismus," Arzneimittelforschung 7, pp. 710-714, (1957).
Translation of Catsch, "Probleme der Chelat-Therapie," Naturwissenschaften, pp. 473-474, (1968).
Morgan et al., "Proton Spin Relaxation in Aqueous Solutions of Paramagnetic Ions, II. Cr.sup.+++, Mn.sup.++, Ni.sup.++, Cu.sup.++ and Gd.sup.+++ ", The Journal of Chem. Physics, vol. 31, No. 2, pp. 365-368, (Aug. 1959).
Eisinger et al., "Transition Metal Binding in DNA Solutions," The Journal of Chemical Physics, vol. 36, No. 7, pp. 1721-1729, (Apr. 1, 1962).
Bertinchamps et al., "Interdependence of Routes Excreting Manganese," Am. J. of Physiology, 211(1), pp. 217-224, (1966).
Goldman et al., (I) [Witchofski et al. (eds)], "Cardiac Applications of NMR Imaging" in NMR Imaging: Proceedings of International Symposium on Nuclear Magnetic Resonance Imaging, Bowman Gray School of Medicine of Wakeforest Univ., N.C., Oct. 1-3, 1981, pp. 171-173.
Kaufman et al., (eds.), Nuclear Magnetic Resonance Imaging in Medicine, Igaku-Shoin Medical Publishers, Inc., (New York), pp. vii-viii, 7, (1981).
Davies, "The Clinical Significance of the Essential Biological Metals," Chapter IV-Manganese, pp. 69-80, (London 1972).
Lauterbur, "Progress in NMR Zeugmatographic Imaging," Phil. Trans. R. Soc. Lond., B. 289, pp. 483-487, (1980).
Derwent Abstract 135A/020, (1975).
Bydder et al., "Clinincal NMR Imaging of the Brain: 140 Cases," AJR 139: pp. 215-236, (Aug. 1982).
Gore et al., "Nuclear Magnetic Resonance (NMR) Imaging at Hammersmith Hospital," SPIE, vol. 273, Application of Optical Instrumentation in Medicine IX, (1981), pp. 8-10.
Article 115 of EPC filing paper (Dec. 4, 1984).
Dwyer et al., Chelating Agents and Metal Chelates, pp. 388-400, Academic Press, Inc., New York, (1964).
Pykett, "NMR Imaging in Medicine," Scientific American 246, pp. 78-88, (May 1982).
Derwent Abstract 07413x/04, (Jan. 13, 1976).
Chemical Abstract, vol. 87:1879b, Logerg et al., (1977).
Derwent Abstract 84974x/46, (Oct. 29, 1976).
Derwent Abstract 221/170, (1977).
Rote Liste, 1977/78, 12 Antidota, p. 12001.
Derwent Abstract 150/429, (1979).
Lauterbur et al., "Augmentation of Tissue Water Proton Spin-Lattice Relaxation Rates by In Vivo Addition of Paramagnetic Ions," Frontiers of Biological Energetics, vol. 1, pp. 752-759, (1978).
Derwent Abstract 144/005, (1979).
Cotzias, "Manganese vs. Magnesium: Why Are They So Similar In Vitro and So Different in Vivo?", Brookhaven Nat'l Lab., Upton, N.Y., pp. 98-103.
Derwent Abstract 78609B/43, (Jan. 30, 1979).
Derwent Abstract 23893B/12, (Mar. 13, 1979).
Derwent Abstract 81534B/45, (Sep. 29, 1979).
Derwent Abstract 05092C/03, (Jan. 1, 1980).
Chemical Abstract, vol. 93:31813s, (Jan. 29, 1980).
Derwent Abstract 02446D/03, (Jan. 7, 1981).
Derwent Abstract 29038D/16, (Apr. 2, 1981).
Chemical Abstract, vol. 95:38681x, Wieder et al., (Mar. 19, 1981).
Derwent Abstract 34726D/20, (May 6, 1981).
Derwent Abstract 124/026, (1981).
Chemical Abstract, vol. 96:115204u, (1982).
Pople et al., High-Resolution Muclear Magnetic Resonance, p. 209, (1959).
Brasch et al., (III), "Contrast-Enhanced NMR Imaging: Animal Studies Using Gadolinium-DTPA Complex," AJR 142, pp. 625-630, (Mar. 1984).
Weinmann et al., "Characteristics of Gadolinium--DPTA Complex: A Potential NMR Contrast Agent," AJR 142, pp. 619-624, (Mar. 1984).
Carr et al., "Intravenous Chelated Gadolinium as a Contrast Agent in NMR Imaging of Cerebral Tumors," The Lancet, (Mar. 3, 1984), pp. 484-486.
Runge et al., (II), "Work in Progress: Potential Oral and Intravenous Paramagnetic NMR Contrast Agents.sup.1," Radiology 147:789-791, (Jun. 1983).
Hansen et al., "In Vivo Imaging of the Rat Anatomy with Nuclear Magnetic Resonance," Radiology 136:695-700, (Sep. 1980).
Sovak [Amiel (ed.)], "Futurology of Contrast Medium: A Partially Warranted Prophecy," Contrast Media in Radiology, pp. 329-335, (Sep. 1981).
Brasch et al., (I), "NSFR: NMR Contrast Agent for the CNS," Symposium Neuroradiologicum, Washington, D.C., Oct. 1982.
Runge et al., (III), "Paramagnetic Agents for Contrast-Enhanced NMR Imaging: A Review," AJR 141, pp. 1209-1215, (Dec. 1983).
Mansfield et al., NMR Imaging in Biomedicine," Advances in Magnetic Resonance, Supplement 2, pp. 232-235, (1982).
Mendonca-Dias et al., "Paramagnetic Contrast Agents in Nuclear Magnetic Resonance Medical Imaging," Seminars in Nuclear Medicine, vol. XIII, No. 4, pp. 364-376, (Oct. 1983).
Hollis et al., "Effect of Manganese Ion on the Phosphorus Nuclear Magnetic Resonance Spectra of the Perfused Rabbit Heart: A Possible New Magnetic Probe," Clin. Res. 26:

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