Sterile bioerodible implant device with a retinoid for improved

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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Details

424422, 424423, 424426, 424427, A61F 1300, A61F 200, A61K 3107

Patent

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06110485&

ABSTRACT:
An implantable device is provided which incorporates a retinoid for improving the biocompatability of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a retinoid for increasing the biocompatibility thereof.

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Giordano et al., Sustained Delivery of Retinoic Acid from Microspheres of Biodegradable Polymer in PVR, Invest. Ophthalmol. Vis. Sci., 34 (9) p2743-51, Aug. 1993.
Kivalo et al., Biodegradable Tube Implants in Experimental Glaucoma Surgery in the Rabbit, Journal of Materials Science-Materials in Medicine v10, n1, p. 53-58, Jan. 1999.

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