Sterically hindered poly (ethylene glycol) alkanoic acids...

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From organic oxygen-containing reactant

Reexamination Certificate

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C528S271000, C424S193100, C424S194100

Reexamination Certificate

active

11264546

ABSTRACT:
The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).

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Topchiyeva, I.N., “Synthesis of Biologically Active Polyethylene Glycol Derivatives. A Review”,Polymer Science U.S.S.R., 1990, pp. 833-851, vol. 32, No. 5.
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