Stereospecific process for the preparation of furo[3,4-c]pyridin

Details Stereospecific process for the preparation of furo[3,4-c]pyridin Stereospecific process for the preparation of furo[3,4-c]pyridin

1989-11-28

1991-06-25

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49148

Patent

active

050268554

ABSTRACT:
The present invention relates to stereospecific processes for the preparation of enantiomers of 3-substituted-furo[3,4-c]pyridine of formula I, wherein R.sub.3, R.sub.4 and R.sub.6 stand for various substituents, comprising the steps of: oxidation of a racemic pyridine derivative of formula II, reduction of the resulting ketone with a reducing agent, sterospecific locking or blocking of the OH group of the enantiomer alcohol, opening of the acetonide ring and cyclization of the resulting compound. ##STR1##

REFERENCES:
patent: 4383998 (1983-05-01), Esanu
patent: 4569938 (1986-02-01), Esanu
patent: 4569939 (1986-02-01), Esanu
patent: 4581362 (1986-04-01), Esanu
patent: 4581363 (1986-04-01), Esanu
patent: 4585776 (1986-04-01), Esanu
patent: 4602020 (1986-07-01), Esanu
patent: 4735950 (1988-04-01), Esanu
Corey et al., Tetrahedron Letters, No. 11, pp. 809-812, 1976.
Terashima et al. J.C.S. Chem. Comm. 1980, pp. 1026-1027.

Affiliated with

Also associated with

Rating

Stereospecific process for the preparation of furo[3,4-c]pyridin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stereospecific process for the preparation of furo[3,4-c]pyridin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereospecific process for the preparation of furo[3,4-c]pyridin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1041152