Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-30
2009-11-17
Coleman, Brenda L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S560000, C540S562000
Reexamination Certificate
active
07618958
ABSTRACT:
The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.
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patent: 0 320 992 (1989-06-01), None
patent: WO 03/082832 (2003-10-01), None
He X et al: “Pharmacophoren/Receptor Models for GABAA/BZR ALPHA3BETA3GAMMA2 and ALPHA4BETA3GAMMA2 Recombinant Subtypes. Included Volume Analysis and Comparison to ALPHA1BETA3GAMMA2, ALPHA5BETA3GAMMA2 and ALPHA6BETA3GAMMA2 Subtypes” Drug Design and Discovery, Hardwood Academic Publishers GMBH, vol. 17, No. 2, 2000.
Zhang, P., et al., “Synthesis of Novel Imidazobenzodiazepines as Probes of the Pharmacophore for ‘Diazepam-Insensitive’ GABAA Receptors,” J. Med Chem. 38:1679-1688 (1995).
Cook James M.
Huang Shengming
Sarma P.V.V. Srirama
Zhang Chunchun
Zhou Hao
Coleman Brenda L
Quarles & Brady LLP
WISYS Technology Foundation, Inc.
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