Stereospecific 5-fu esters and methods for preparing same

Details Stereospecific 5-fu esters and methods for preparing same Stereospecific 5-fu esters and methods for preparing same

1996-06-28

1998-09-15

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2853, 536115, 536119, 536124, C07H 100, C07H 1906

Patent

active

058080490

ABSTRACT:
There is disclosed an ester compound that is resistant to decomposition in blood, but is quickly hydrolyzed in cancer cells, and functions as an anticancer agent. The ester compound has a structure represented by formula (I) or formula (II): ##STR1## wherein R.sub.1 represents a methyl group, a methoxy group, or a trifluoroacetamido group; R.sub.2 represents a phenyl group or a phenylmethyl group; and the absolute configuration of the asymmetric center marked with an asterisk is R.

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patent: 4757139 (1988-07-01), Kawaguchi et al.
patent: 5032680 (1991-07-01), Kawai et al.
A Collection of the Substance of a Lecture, p. 36, vol. 4, Mar. 5, 1994.

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