Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1987-04-15
1989-08-15
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
562429, 562463, C07C14940
Patent
active
048576590
ABSTRACT:
The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (.beta.S,.gamma.R) and (.beta.R,.gamma.S)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio -.gamma.-hydroxy-.beta.-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular, disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.
REFERENCES:
R. Frenette et al., J. Org. Chem., 52, 304-307, 1987.
Ann. Rpts. in Med. Chem., 19, D. M. Bailey ed., 241-251, 1984.
Frenette Richard
Gauthier Jacques-Yves
Kakushima Masatoshi
Verhoeven Thomas R.
Young Robert N.
Killos Paul J.
Lopez Gabriel
Merck Frosst Canada Inc.
Pfeiffer Hesna J.
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