Stereoselective reduction of substituted oxo-butanes

Details Stereoselective reduction of substituted oxo-butanes Stereoselective reduction of substituted oxo-butanes

2006-08-01

2006-08-01

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C435S157000, C435S156000, C435S252100

Reexamination Certificate

active

07083973

ABSTRACT:
The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species ofRhodococcusandBrevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.

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