Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihy

Details Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihy Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihy

1992-09-02

1993-06-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

554125, 554190, 554213, 554214, 554218, 558250, 564170, 568 6, C07C 6976

Patent

active

052181383

ABSTRACT:
This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one and a sterically hindered dialkylated borane to form a complex at about -50.degree. C. to about 0.degree. C., and reducing the complex with hydride at about -25.degree. C. to about 50.degree. C.

REFERENCES:
patent: 2712527 (1955-07-01), Mikeska
patent: 2831005 (1958-04-01), Walton
patent: 4248889 (1981-02-01), Oka
patent: 5066815 (1991-11-01), Sayo et al.
patent: 5093363 (1992-03-01), Kita et al.

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