Stereoselective production of hydroxyamide compounds from chiral

Details Stereoselective production of hydroxyamide compounds from chiral Stereoselective production of hydroxyamide compounds from chiral

1991-07-02

1992-12-08

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

548217, 560 28, 544165, C07C27120, C07D26352, C07D295104

Patent

active

051699524

ABSTRACT:
An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: ##STR1## comprises the addition of metalated amide enolates to chiral .alpha.-amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.

REFERENCES:
Marshall et al, Journal of Organic Chemistry, vol. 50 (1985) pp. 1602-1606.

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