Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2011-06-07
2011-06-07
Ariani, Kade (Department: 1651)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
C435S118000, C435S135000, C435S088000, C435S019000, C514S04400A
Reexamination Certificate
active
07955835
ABSTRACT:
The present invention relates to a process for producing compounds of formula (I) and (VII); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compounds of formula (I) and (VII). The invention also provides a process for producing compounds of formula (III) and (X); said process comprising the steps of: a) subjecting a compound of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen fromCandida Antarctica“A” lipase,Candida Antarctica“B” lipase,Candida LypoliticaLipase orRhizomucor MieheiLipase b) recovering said compound of formula (III) and (X).
REFERENCES:
patent: 2001/0049372 (2001-12-01), Nguyen-Ba
patent: WO 0039143 (2000-07-01), None
patent: WO 00/47759 (2000-08-01), None
patent: WO 0047759 (2000-08-01), None
Ferrero et al., Monatshefte für Chemie, 2000, vol. 131, p. 585-616.
Adler et al., JBC, 1961, vol. 236, No. 12, p. 3240-3245.
Martinelle et al., Biochimica et Biophysica Acta, 1995, vol. 1258 p. 272-276.
Janes et al: “Protease -Mediated Separation of Cis and Trans Diastereomers of 2(R,S)- benzyloxymethy1-4(S)-carboxylic Acid 1,3-Dioxolane Methy Ester: Intermediates for the Synthesis of Dioxolane Nucleosides” Journal of Organic Chemistry, American Chemical Society, Easton, US, vol. 64, Nov. 19, 1999, pp. 9019-9029, XP002137411.
Cimpoia Alex
LaLonde James Joseph
Ariani Kade
Millen White Zelano & Branigan P.C.
SHIRE Canada Inc.
LandOfFree
Stereoselective process for the production of dioxolane... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stereoselective process for the production of dioxolane..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereoselective process for the production of dioxolane... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2681310