Stereoselective process for producing dihydro-2,3-benzodiazepine

Details Stereoselective process for producing dihydro-2,3-benzodiazepine Stereoselective process for producing dihydro-2,3-benzodiazepine

1995-03-28

1997-09-09

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

549442, 549443, C07D40502, C07D40504

Patent

active

056658788

ABSTRACT:
A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to the desired enantiomer. The reduction step may be carried out by an enzymatic reduction.

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