Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-09-17
2000-02-15
Lambkin, Deborah C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D20708
Patent
active
060255005
ABSTRACT:
The invention relates to an improved stereoselective heterogenous catalytic reductive amination between ethyl 2-oxo-4-phenylbutyrate and alanylproline using hydrogen, a catalyst and one or more additives to produce the ACE inhibitor, enalapril.
REFERENCES:
patent: 5319098 (1994-06-01), Burbaum et al.
patent: 5473081 (1995-12-01), Kobayashi et al.
patent: 5670655 (1997-09-01), Qin et al.
patent: 5707991 (1998-01-01), Capet et al.
patent: 5898076 (1999-04-01), Giselbrecht et al.
patent: 5962696 (1999-10-01), Tanner et al.
patent: 5977380 (1999-11-01), Yang et al.
Blacklock et al, "Synthesis of Semisynthetic Dipeptides Using N-Carboxyanhydrides and Chiral Induction on raney Nickel", J. Org. Chem., 1988, 53, 836-844.
Huffman Mark A.
Leblond Carl
Reider Paul J.
Sun Yongkui
Camara Valerie J.
Daniel Mark R.
Lambkin Deborah C.
Merck & Co., Ltd.
LandOfFree
Stereoselective process for enalapril does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stereoselective process for enalapril, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereoselective process for enalapril will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1907137