Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1996-01-04
1997-04-08
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435120, 435280, C12P 742, C12P 1714
Patent
active
056187076
ABSTRACT:
A stereoselective reduction of compound II to compound of formula I ##STR1## which comprises adding ketone substrate II to a culture broth of the Zygosaccharomyces bailii ATCC 38924, incubating the resulting mixture, and isolating a hydroxy compound of formula I, is described. The resulting compound of formula I is useful as an intermediate in the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)propyl]-4(S)-(4-hy droxyphenyl)-2-azetidinone which is a serum cholesterol lowering agent. Also described is a stereoselective reduction of a compound of formula IV to compound of formula III ##STR2## using Schizosaccharomyces octosporus ATCC 2479.
REFERENCES:
patent: 4879233 (1989-11-01), Charney
patent: 5371014 (1994-12-01), Matsuyama et al.
Page entitled "Biological Reductions" information presented at a meeting Oct. 1994.
Page entitled "Ketone Substrates" information presented at a meeting Oct. 1994.
Page entitled "Cultures to screen for carbonyl reduction" information presented at a meeting Sep. 28, 1995.
Page entitled "Summary of selected microbes and growth media, etc. . . . " information presented at a meeting Sep. 28, 1995.
Page entitled "Substrate specificity of alcohol dehydrogenase from Hansenula subellicosa" information presented at a meeting Sep. 28, 1995.
Page entitled "Symposium Programme" which lists Sep. 28, 1995 presentation by Dr. David R Dodds (No Publication Date).
Homann Michael J.
Previte Edward
Boxer Matthew
Maitner John J.
Saucier S.
Schering Corporation
Wityshyn Michael G.
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