Stereoselective microbial reduction for the preparation of 1-(4-

Details Stereoselective microbial reduction for the preparation of 1-(4- Stereoselective microbial reduction for the preparation of 1-(4-

1999-02-23

2000-10-17

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435280, C12P 1710

Patent

active

061330019

ABSTRACT:
A process for the stereoselective microbial reduction of compound of formula II to compound of formula I ##STR1## comprising adding compound of formula II to a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solvent containing a microorganism, preferably Rhodococcus fascians ATCC No. 202210 or fungal isolate Geotrichum candidum ATCC No. 74487, incubating the resulting mixture, and isolating a hydroxy compound of formula I, is described. The compound of formula I is a serum cholesterol lowering agent.

REFERENCES:
patent: 5618707 (1997-04-01), Homann et al.
patent: 5767115 (1998-06-01), Rosenblaum et al.
Derwent Abstract 86-208964 of JP61141894.
Santaniello et al, Chem. Rev., 92(1992), p. 1071-1087.
Belan et al, J. Org. Chem., 52 (1987), p. 256-260.

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