Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1992-05-15
1994-06-28
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435121, 435135, 435822, 435872, 435938, C12P 4100, C12P 1710, C12P 762
Patent
active
053246624
ABSTRACT:
Microorganisms or reductases derived therefrom reduce a diketo ester ##STR1## to form the associated 3-hydroxy, 5-hydroxy, or 3,5-dihydroxy esters. Selected microorganisms produce the preferred stereoisomers ##STR2## which can be used to prepare antihypercholesterolemic agents such as ##STR3##
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Banerjee Amit
McNamee Clyde G.
Patel Ramesh N.
Szarka Laszlo J.
E. R. Squibb & Sons Inc.
Gaul Timothy J.
Robinson Douglas W.
Saucier S.
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