Stereoselective glycosylation process for preparing 2'-Deoxy-2',

Details Stereoselective glycosylation process for preparing 2'-Deoxy-2', Stereoselective glycosylation process for preparing 2'-Deoxy-2',

1993-04-07

1997-01-14

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 100, C07H 106, C07H 1906

Patent

active

055941249

ABSTRACT:
A stereoselective glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides which involves reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorocarbohydrate with at least a molar equivalent of a pyrimidine nucleobase derivative in a low freezing inert solvent.

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