Stereoselective glycosylation process for preparing 2'-deoxy-2',

Details Stereoselective glycosylation process for preparing 2'-deoxy-2', Stereoselective glycosylation process for preparing 2'-deoxy-2',

1993-04-07

1998-10-13

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 267, 536 284, C07H 100, C07H 19073, C07H 19173

Patent

active

058213570

ABSTRACT:
A stereoselective glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoropurine and triazole nucleosides and 2'-deoxy-2'-fluoropurine and triazole nucleosides which involves reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorocarbohydrate with at least a molar equivalent of a nucleobase derivative in a low freezing inert solvent.

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