Stereoselective fusion glycosylation process for preparing 2'-de

Details Stereoselective fusion glycosylation process for preparing 2'-de Stereoselective fusion glycosylation process for preparing 2'-de

1992-06-22

1994-12-06

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2712, 536 2721, 536 276, 536 278, 536 2781, 536 281, 536 283, 536 284, 536 285, 536 2852, 536 2853, 536 2854, 536 2855, C07H 100, C07H 1900

Patent

active

053712102

ABSTRACT:
A stereoselective fusion glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides is provided which requires reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorocarbohydrate with at least 3 molar equivalents of a nucleobase derivative at a temperature sufficient to fuse the carbohydrate and nucleobase; in the absence of a catalyst and a solvent.

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