Stereoselective antifibrillogenic peptides and...

Details Stereoselective antifibrillogenic peptides and... Stereoselective antifibrillogenic peptides and...

2006-06-13

2006-06-13

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S007600, C514S008100, C530S328000, C530S329000, C530S300000, C530S350000, C436S009000

Reexamination Certificate

active

07060670

ABSTRACT:
The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot—prot interaction region of the amylo protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for vivo imaging of amyloid deposits.

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