Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2009-01-16
2011-10-04
Rao, Deepak (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S295000, C544S323000
Reexamination Certificate
active
08030483
ABSTRACT:
The present invention provides stereoisomers and stereoisomeric mixtures of 3-amino carbonyl-bicycloheptene-2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
REFERENCES:
patent: 5962312 (1999-10-01), Plowman
patent: 5972676 (1999-10-01), Plowman
patent: 6207401 (2001-03-01), Plowman
patent: 6342503 (2002-01-01), Aldrich
patent: 6593326 (2003-07-01), Bradbury et al.
patent: 6841579 (2005-01-01), Plowman
patent: 6908920 (2005-06-01), Thomas
patent: 7060827 (2006-06-01), Singh et al.
patent: 7173028 (2007-02-01), Dahmann et al.
patent: 7511137 (2009-03-01), Li
patent: 2003/0139435 (2003-07-01), Ahmed et al.
patent: 2003/0162802 (2003-08-01), Guo
patent: 2003/0171359 (2003-09-01), Dahman
patent: 2004/0029902 (2004-02-01), Singh et al.
patent: 2004/0102630 (2004-05-01), Brumby
patent: 2004/0224966 (2004-11-01), Brumby
patent: 2004/0265852 (2004-12-01), Plowman
patent: 2005/0002938 (2005-01-01), Plowman
patent: 2005/0113398 (2005-05-01), Argade et al.
patent: 2005/0176743 (2005-08-01), Luecking
patent: 2005/0192301 (2005-09-01), Li et al.
patent: 2005/0203114 (2005-09-01), Armistead
patent: 2005/0209224 (2005-09-01), Singh et al.
patent: 2005/0209230 (2005-09-01), Singh et al.
patent: 2005/0234049 (2005-10-01), Singh et al.
patent: 2006/0025410 (2006-02-01), Singh et al.
patent: 2006/0035891 (2006-02-01), Li et al.
patent: 2006/0035916 (2006-02-01), Singh et al.
patent: 2006/0040955 (2006-02-01), Singh et al.
patent: 2006/0058292 (2006-03-01), Singh et al.
patent: 2006/0058525 (2006-03-01), Singh et al.
patent: 2006/0135543 (2006-06-01), Singh et al.
patent: 2006/0166308 (2006-07-01), Argade
patent: 2006/0167254 (2006-07-01), Cooper et al.
patent: 2006/0270694 (2006-11-01), Wong
patent: 2007/0032514 (2007-02-01), Zhan et al.
patent: 2007/0179140 (2007-08-01), Argade et al.
patent: 2007/0299060 (2007-12-01), Li et al.
patent: 2008/0009494 (2008-01-01), Li et al.
patent: WO 95/10506 (1995-04-01), None
patent: WO 97/22702 (1997-06-01), None
patent: WO 00/03032 (2000-01-01), None
patent: WO 01/60816 (2001-08-01), None
patent: WO 02/04429 (2002-01-01), None
patent: WO 02/059110 (2002-08-01), None
patent: WO 02/096888 (2002-12-01), None
patent: WO 02/102313 (2002-12-01), None
patent: WO 03/002544 (2003-01-01), None
patent: WO 03/026664 (2003-04-01), None
patent: WO 03/030909 (2003-04-01), None
patent: WO 03/032997 (2003-04-01), None
patent: WO 03/040141 (2003-05-01), None
patent: WO 03/055489 (2003-07-01), None
patent: WO 2004/014382 (2004-02-01), None
patent: WO 2005/035507 (2005-04-01), None
patent: WO 2005/037800 (2005-04-01), None
patent: WO 2005/063722 (2005-07-01), None
patent: WO 2005/118544 (2005-12-01), None
patent: WO 2006/078846 (2006-07-01), None
Forro, et al.: “Vapor-assisted enzymatic hydrolysis of beta-lactams in a solvent-fee system,” Tetrahedron: Asymmetry, 2008, pp. 1005-1009, vol. 19, Elsevier, Oxford, United Kingdom.
Rogers, et al.: “The aurora kinase AIR-2 functions in the release of chromosome cohesion inCaenorhabditis elegansmeiosis,” Journal Cell Biology, Apr. 2002, vol. 157(2): pp. 219-229.
Tanaka, et al.: “Evidence that the Ip11-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetocheore-spindle pole connections,” Cell, Feb. 2002, vol. 108(3):pp. 317-329.
Ulrich, JOachim, “Chapter4: Crystallization,” Kirk-Othmer Encyclopedia of Chemical Technology, Aug. 2002.
Vippagunta, et al.: “Crystalline solids,” Advanced Drug Delivery Reviews, 48, 2001, pp. 3-26.
West, Anthony, “Chapter 10: Solid Solutions,” Solid State Chemistry and its applications, 2001, p. 358 and 365.
Simone, Oncology: Introductions, Cell Textbook of Medicind, 20th Edition, vol. 1, pp. 1004-1010, 1996.
Cuiper, Anne Dite: “Molecular docking with Candida Antarctica Lipase B1,” Enantioselective Synthesis of Lactams and Lactones: a Chemo-Enzymatic Approach, Chapter 10, 1999, pp. 133-140; http://dissertations.ub.rug.nl/oai.
Adam et al.: Synthesis of Optically Active x-Methyklene B0Lactams Through Lipase-Catalyzed Kinetic Resolutions, J. Org. Chem. 65:4919-4922, 2000.
Forro et al.: “Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic B-Amino Acids and Derivatives from B-Lactams,” Mini=-Reviews in Organic Chemistry, 1(1):93-102, 2004.
Kurokawa et al.: “Both Enantiomers of N-Boc-indoline-2-carboxylic Esters,” Bull. Chem. Soc. Jpn. 77:1021-1025, 2004.
Parker et al.: “Enhancement of Candida Antarctica Lipase B Enantioselectivity and Activity in Organic Solvents,” Chem. Commun. pp. 2247-2248, 1998.
Torre et al.: “Lipase Catalysed Michael Addition of secondary Amines to Acrylonitrile,” Chem. Commun., pp. 1724-1725, 2004.
Gura, Systems for identifying New Drugs Are Often Faulty, Cancer Models, Science, vol. 278, No. 5340, pp. 1041-1042, Nov. 1997.
Johnson et al., Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials, British Journal of Cancer (2001) 64(10): 1424-1431.
Lin-Yu Lu et al.: “Aurora A Is essential for Early Embryonic Development and Tumor Suppression,” Journal of Biological Chemistry, vol. 283, No. 46, Nov. 14, 2008, pp. 31785-31790.
Elizabeth A. Harrington et al.: “VX-680, a potent and selective small-molecule inhibitor of the aurora kinases, suppresses tumor growth in vivo,” Nature Medicine, vol. 10, No. 3, Mar. 2004, pp. 262-267.
Argade Ankush
Li Hui
Singh Rajinder
McDonnell Boehnen & Hulbert & Berghoff LLP
Rao Deepak
Rigel Pharmaceuticals Inc.
Young Travis
LandOfFree
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stereoisomerically enriched 3-aminocarbonyl bicycloheptene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereoisomerically enriched 3-aminocarbonyl bicycloheptene... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4268499