Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic

Details Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic

1992-03-02

1994-09-13

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435829, C12P 4100

Patent

active

053468287

ABSTRACT:
Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3-phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid is treated with D-threonine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.

REFERENCES:
patent: 3871958 (1975-03-01), Nakazawa et al.
patent: 4235892 (1980-11-01), Nagabhushan
patent: 4492757 (1985-01-01), Kato et al.
patent: 4582918 (1986-04-01), Nagabhushan et al.
patent: 4677214 (1987-06-01), Nagabhushan et al.
patent: 4945181 (1990-07-01), Dick et al.
Cambou B. et al, Biotechnol and Bioengineering XXVI:1449-1454 (1984).
Jones J., Tetrahedron 42:3351-3403 (1986).
Cutler et al., JACS, 74, 5475-5481, 1952.
Suter et al., JACS, 75, 4330-4333, 1953.
Kleeman et al., Pharmazeutische Wirkstoffe, 874-875, 1987.
Drugs of the Future, VII, No. 3, 172-174, 1982.

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