Stereochemical Wortmannin derivatives

Details Stereochemical Wortmannin derivatives Stereochemical Wortmannin derivatives

1994-07-01

1996-01-02

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549275, A61K 31365, C07D31178

Patent

active

054809061

ABSTRACT:
This invention relates to derivatives of Wortmannin and particularly to 11,17 substituted derivatives of Wortmannin. The invention also relates to a method of using these compounds as PI-3-kinase inhibitors and as anti-tumor agents.

REFERENCES:
patent: 3668222 (1972-06-01), Hauser
patent: 4988682 (1991-01-01), Kozikowski
Yano, Hiroshi, et al., Journal of Biological Chemistry, vol. 268 (34), pp. 25846-25856 (1993).
Kimura, K., et al., Ninth Annual Meeting on Oncogenes, Abstract: p. 203 (1993).
Matter, W. F., et al., Biochem. Biophys. Res. Commun., 186(2): pp. 624-631 (1992).
Haeflinger, W., et al., Helv. Chem. Acta, 56(8): pp. 2901-2904 (1973).
MacMillan, J., et al., J. Chem. Soc. Perkin I, pp. 2892-2898 (1972).
Abbas, H. K., et al., Appl. Environ. Microbiol., 54(5): pp. 1268-1274 (1988).
Shibasaki, F., et al., J. Biol. Chem., 266(13): pp. 8108-8114 (1991).
Nakanishi, S., et al., J. Biol Chem., 267(4): pp. 2157-2163 (1992).
Ohara-Imaizumi, M., et al., Biochem. Biophys. Res. Commun., 185(3): pp. 1016-1021 (1992).
Kaplan, D. R., et al., Cell, 50: pp. 1027-1029 (1987).
Valius, M., et al., Cell, 73: pp. 321-334 (1993).
Coughlin, S. R., et al., Science, 243: pp. 1191-1194 (1989).
Baggiolini, M., et al., Exp. Cell Res., 169: pp. 408-418 (1987).

Affiliated with

Also associated with

Rating

Stereochemical Wortmannin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stereochemical Wortmannin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stereochemical Wortmannin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-235525