Stereo and enantioselective synthesis of tetrahydro-5-substitute

Details Stereo and enantioselective synthesis of tetrahydro-5-substitute Stereo and enantioselective synthesis of tetrahydro-5-substitute

1991-05-10

1992-10-06

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549555, C07D30720

Patent

active

051533375

ABSTRACT:
Novel processes and intermediates for the preparation of tetrahydro-5-hydroxy-3-methylene-2-furan-methanol and of tetrahydro-5-[lower alkoxy (C.sub.1 -C.sub.3)]-3-methylene-2-furanmethanol useful as intermediates in the synthesis of various modified nucleosides having antiviral and other biological activity.

REFERENCES:
patent: 4772727 (1988-09-01), Sutherland et al.
Fleet, G. W., Tetrahedron, 1988, 44(2): 625-636.
Bravo, P. et al., J. Org. Chem., 1989, 54: 5171-5176.
Y. Gao et al., J. Amer. Chem. Soc., 1987, 109: 5665-5780.
Kochetkov, N. K. et al., Tetrahedron Lett., 1981, 22(43): 4315-4318.

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