Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
1999-09-07
2001-09-18
Owens, Amelia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S254010, C544S338000, C544S339000
Reexamination Certificate
active
06291461
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel antitumor antibiotics, designated by the present inventors as stephacidin A and stephacidin B, which may be obtained by cultivation of a strain of
Aspergillus ochraceus.
The antibiotics provided by the present invention are useful in inhibiting tumors in mammals.
2. Background Art
The present inventors are not aware of any literature disclosing stephacidin A or B or any compounds closely related in structure.
SUMMARY OF THE INVENTION
The present invention provides the novel antibiotics designated by the present inventors as stephacidin A and stephacidin B and a fermentation process for production of these antibiotics using a novel strain of
Aspergillus ochraceus
designated herein as
Aspergillus ochraceus
WC76466 (ATCC-74432). The antibiotics of the present invention have been found to be useful for the inhibition of tumors, particularly prostate carcinoma, in mammals.
Also provided are pharmaceutical compositions of stephacidin A and B, methods for the inhibition of mammalian tumors using the antibiotics of the present invention and processes for obtaining the antibiotics, including substantially purified forms thereof.
Chang Li-Ping
Cutrone Jingfang Qian
Krampitz Kimberly D.
Lowe Susan E.
Shu Yue-Zhong
Bristol--Myers Squibb Company
Morse David M.
Owens Amelia
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