Stent sheath for local drug delivery

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure

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623 12, 606194, A61F 206, A61F 204

Patent

active

053839285

ABSTRACT:
This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.

REFERENCES:
patent: 4687482 (1987-08-01), Hanson
patent: 4776337 (1988-10-01), Palmaz
patent: 4929602 (1990-05-01), Harker et al.
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5037378 (1991-08-01), Mueller et al.
patent: 5102417 (1992-04-01), Palmaz
Murphy et al., "Polymeric Stents: Modern Alchemy or the Future?", The Journal of Invasive Cardiology 3:144-148 (1991).
Bailey et al., "Polymer Coating of Palmaz-Schatz Stent Attenuates Vascular Spasm After Stent Placement," Circulation 82:III-541 (1990).
Cavender et al., "The Effects of Heparin Bonded Tantalum Stents on Thrombosis and Neointimal Proliferation," Circulation 82:III-541 (1990).
van der Geissen et al., "Self-expandable Mesh Stents: An Experimental Study Comparing Polymer Coated and Uncoated Wallstent Stents in the Coronary Circulation of Pigs," Circulation 82:III-542 (1990).

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