Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-26
1999-01-05
Allen, Marianne P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530351, 530399, 514 2, A61K 3819
Patent
active
058563016
ABSTRACT:
Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1.alpha. which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.
REFERENCES:
patent: 4929555 (1990-05-01), Cregg et al.
Graham et al., Nature, 344:422 (1990).
Schall, Cytokine, 3:165-183 (1991).
Dunlop et al., Blood, 79:2221-2225 (1992).
Oppenheim et al., Annual Rev. Immunol., 9:617-648 (1991).
Clore et al., Biochemistry, 29:1689-1696 (1990).
Gronenborn and Clore, Protein Engineering, 4:263-269 (1991).
Lodi et al., Science, 263:1762-1767 (1994).
McKie and Douglas, Drug Design and Discovery, 11:47-59 (1994).
Skelton et al., Biochemistry, 34:5329-5342 (1995).
Chung et al., Biochemistry, 34:9307-9314 (1995).
Covell et al., Protein Science, 3:2604-2072 (1994).
Broxmeyer et al., J. Immunology, 150(8):3448-3458 (1993).
Mantel et al., Expt. Haematol., 20: No. 368, 800 (1992).
Graham & Pragnell, Dev. Biol., 151:377-381 (1992).
Graham et al., Growth Factors, 7(2):150-160 (1992).
Lord et al., Blood, 79 No. 10, 2605-2609 (1992).
Paukovits, et al., Molecular Pharmacology, 38, pp. 401-409.
Craig Stewart
Czaplewski Lloyd George
Edwards Richard Mark
Gilbert Richard James
Hunter Michael George
Allen Marianne P.
British Biotech Pharmaceuticals Limited
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