Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-01-03
1998-09-15
Fitzgerald, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303587, 5303913, 5303917, 4241441, 4241781, 435 724, 435 34, 435334, 435343, 4353431, 435346, 435377, 4353723, 436538, C07K 1628, C12N 520, A61K 39395, C12Q 33577
Patent
active
058080023
ABSTRACT:
The present invention relates to a monoclonal antibody that binds specifically to a human stem cell factor (SCF) receptor. The invention further relates to hybridoma cells that produce such an antibody, and to a method for generating such hybridoma cells.
REFERENCES:
patent: 5489516 (1996-02-01), Broudy et al.
patent: 5545533 (1996-08-01), Bartke et al.
Blechmann, J. et al.: "Soluble c-Kit Proteins and Antireceptor Monoclonal Antibodies Confine the Binding Site of the Stem Cell Factor"; J. Biological Chemistry, vol. 268 No. 6 Issue of Feb. 25, pp. 4399-4406 (1993).
Morita, S. et al.: "Isolation and Characterization of Two Monoclonal Antibodies that Recognize Different Epitopes of the Human c-kit Receptor", Tohaku J. Exp. Med., pp. 178, 187-198 (Feb. 1996).
Buhring, H. et al.: "Leucocyte Typing V, CR2.7 Stem-Cell Factor Receptor (p145(c-kit) Summary Report (CD117)", Oxford University Press, pp. 1882-1888 (1995).
Zsebo, K. et al.: "Stem Cell Factor Is Encoded at the SI Locus of the Mouse and is the Ligand for the C-kit . . . ", Cell vol. 63, pp. 213-224 (1990).
Buhring, H. et al.: "The Monoclonal Antibody 11G7 Recognizes a Novel Differentiation Antigen Expressed . . . ", Hybridoma vol. 10, No. 1, pp. 77-88 (1991).
Matsuo, Y. et al.: "Establishment and Characterization of a Novel Megakaryoblastoid Cell Line . . . "; Human Cell 4, pp. 261-264 (1991).
Eberhard-Karls-Universitat Tubingen
Fitzgerald David L.
Hamrick Claude A.S.
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