Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1997-10-21
1999-10-19
Saunders, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 435 691, 435325, 514 2, 514 8, 536 234, 536 235, C12P 2100, A61K 3816, C07H 2104, C07K 100
Patent
active
059691050
ABSTRACT:
The present invention is drawn to human stem cell factor receptor agonist polypeptides, nucleic acid molecules encoding same, methods of producing the agonist polypeptides from the nucleic acid sequences and therapeutic compositions comprising the agonist polypeptides. The polypeptides of the instant invention are derived from the sequnce of SEQ ID NO:1, wherein 1-23 amino acids are optionally deleted from the C-terminus and the N-terminus is joined to the C-terminus, either directly or through a linker and C- and N-termini are created between an amino acid pair chosen from 23-24 through 110-111 of SEQ ID NO:1, generating said human stem cell factor receptor agonist polypeptide. The human stem cell factor receptor agonist polypeptide may additionally be immediately be preceded by a (methionine.sup.-1), (alanine.sup.-1) or (methionine.sup.-2, alanine.sup.-1).
REFERENCES:
patent: 5635599 (1997-06-01), Pastan et al.
Reeke et al, "Three-Dimensional Structure of Favin: Saccharide Binding-Cyclic Permutation in Leguminous Lectins", Science, Nov. 28, 1986, vol. 234 pp. 1108-1111.
Luger et al, "An 8-fold Ba Barrel Protein with Redundant Folding Possibilities", Protein Engineering, vol. 3 pp. 249-258.
Cunningham et al, "Favion versus concanavalin A: Circularly permuted amino acid sequences", Proc. Natl. Acad. Sci. USA, Jul. 1979, vol. 76, No. 7, pp. 3218-3222.
Protasova et al, Circularly permuted dihydrofolate reductase of E. coli has functional activity and a destabilzed tertiary structure:, Protein Engineering, 1994, vol. 7, No. 11, pp. 1373-1777.
Zhang et al, "Circular Permutation of T4 Lysozyme", Biochemistry, vol. 32, No. 46, 1993.
Luger et al, "Correct Folding of Circularly Permuted Variants of a Ba Barrel Enzyme in Vivo", Science, vol. 243.
Hahn et al, "Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis", Proc. Natl. Acad. Sci. USA, 1994, vol. 91, pp. 10417-10421.
Lin et al, "Rearranging the domains of pepsinogen", Protein Science, 1995, vol. 4, pp. 159-166.
Yang et al, "Aspartate transcarbamoylase containing circularly permuted catalytic polypeptide chains", Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 11980-11984.
Vignai et al, "Circular permutation within the coenzyme binding domain of the tetrameric glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus", Protein Science, 1995, vol. 4., pp. 994-1000.
Goldenberg et al, "Circular and Circularly Permuted Forms of Bovine Pancreatic Trypsin Inhibitor", J. Mol. Biol.1983 vol. 165, pp. 407-413.
Hemperly et al, "Circular permutation of amino acid sequences among legume lectins", TIBS, 1983, pp. 100-102.
Kreitman et al, "Circularly permuted interelukin 4 retains proliferative and binding activity", Cytokine, 1995, vol. 7, No. 4, pp. 311-318.
Li et al, "Degradation of Ornithine Decarboxylase", Mol. and Cel. Biol. 1993, vol. 13, No. 4, pp. 2377-2383.
Ritco et al, "Is the Continuity of the Domains Required for the Correct Folding of a Two-Domain Protein?", Biochemistry, 1995, vol. 34, pp. 16543-16551.
Garrett et al, "Are turns required for the folding of ribonuclease T1?", Protein Science, 1996, vol. 5., pp. 204-211.
Komar et al, "Kinetics of translation" FEBS Letters, 1995 vol. 376, pp. 195-198.
MacGregor et al, "A cicularly permuted a-amylase-type", FEBS Letters, 1996, vol. 378, pp. 263-266.
Koebnik et al, "Membrane Assembly of Circulary Permuted Variants", JMB, 1995, vol. 250, pp. 617-626.
Buchwalder et al, "A fully active variant of Dihydrofolate Reductase with a circularly permuted sequence", Biochemistry, 1992, vol. 31, pp. 1621-1630.
Viguera et al, "The order of secondary structure elements", J. Mol. Biol., 1995, vol. 247, pp. 670-681.
Mullins et al. "Transposition of Protein Sequences: Circular Permutation of Ribonuclease T1", J. Am. Chem. Soc., 1994, vol. 116, pp. 5529-5533.
Horlick et al, "Permuteins of interleukin 1B--a simplified approach for the construction of permutated proteins having new termini", Protein Engineering, USA, 1992, vol. 5, pp. 427-431.
Kreitman et al, "A circularly permuted recombinant interleukin 4 toxin with increase activity", Proc. Natl. Acad. Sci. USA, 1993, vol. 91, pp. 6889-3893.
Martin et al, "Primary Structure and Funtional Expression of Rat and Human Stem Cell Factor DNAs", Cell, vol. 63, 1990, pp. 203-211.
Feng Yiqing
McWherter Charles A.
Saunders David
VanderVegt F. Pierre
LandOfFree
Stem cell factor receptor agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stem cell factor receptor agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stem cell factor receptor agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2056823