Stearoyl-CoA desaturase 4 gene

Details Stearoyl-CoA desaturase 4 gene Stearoyl-CoA desaturase 4 gene

2007-10-23

2007-10-23

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

C435S069100, C435S325000, C435S320100, C435S190000, C536S023200

Reexamination Certificate

active

11147606

ABSTRACT:
The cloning of a fourth mouse SCD gene, mSCD4, as well as its corresponding cDNA and amino acid sequences are disclosed. Mouse SCD4 is expressed mainly in the heart tissue and synthesizes the bulk of monounsaturated fatty acids in the heart. The disclosure here enables new tools (e.g., nucleic acids, polypeptides, antibodies, vectors, recombinant cells, and transgenic and knock-out animals) for studying the function of various SCD isoforms and their connection to various disease conditions. New tools for converting saturated fatty acyl-CoA to monounsaturated acyl-CoA and for identifying SCD modulators including isoform-specific modulators are also enabled. In addition, given that accumulation of lipid in the heart (fatty heart) can have deleterious consequences, the present invention also provides a new prevention and treatment target for fatty heart as well as methods for screening candidate drugs.

REFERENCES:
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Scd3—A Novel Gene of the Stearoyl-CoA Desaturase Family with Restricted Expression in Skin; Zheng, Y. et al. (2001) Genomics 71, 182-191.
Identification and Characterization of a Novel Gene Disrupted by a Pericentric Inversion . . . ; Beiraghi, S. et al. (2003) Gene 309, 11-21.
Identification and Characterization of Murine SCD4 . . . ; Miyazaki, M. et al. (2003) J. Biol. Chem. 278, 33904-33911.
Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes; Kaestner, K. H. et al. (1989) J. Biol. Chem. 264, 14755-14761.
Mus musculusStearoyl-CoA Desaturase 4; GenBank Accession No. NM—183216, Apr. 2, 2004.
Homo sapiensStearoyl-CoA Desaturase 4; GenBank Accession No. NM—024906, Jan. 1, 2004.

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