Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-03-21
1999-02-02
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
435455, 435462, 435463, 435325, 4353201, 435 921, 424 921, C12N 500, C12N 1500, C12N 1509
Patent
active
058667601
ABSTRACT:
The invention provides methods and compositions for evaluating modulators of the Stat6 signaling pathway; in a particular, transgenic mice comprising a transgene within a Stat6 allele locus, encoding a selectable marker and displacing the SH2-encoding domain of the Stat6 allele. More particularly, the transgene may comprise 3' and 5' regions with sufficient complementarity to the natural Stat6 allele at the locus to effect homologous recombination of the transgene with the Stat6 allele. Such mice provide useful animal models for determining the effect of candidate drugs on a host deficient in Stat6 function. The invention provides a variety of methods for making and using the subject compositions; in particular, methods for determining the effect of a candidate drug on a mouse deficient in Stat6 function and methods of evaluating the side effects of a Stat6 function inhibitor.
REFERENCES:
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Mullins et al. Journal of Clinical Investigations, vol. 98. No. 11, pp S37-S40, 1996.
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Copies of pages from lab notebook (4p).
Keystone symposium agenda (6p).
St. Jude Children's Research Hospital interoffice memorandum (2p).
Grusby Michael J.
Kaplan Mark H.
Chambers Jasemine C.
Martin Jill D.
Osman Richard Aron
President and Fellows of Harvard College
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