Starting materials in the synthesis of thrombin and kininogenase

Organic compounds -- part of the class 532-570 series – Organic compounds

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514210, 548953, C07D21300

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active

057806314

ABSTRACT:
The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing serine protease inhibitors. The invention further concerns an improved method for synthesizing serine protease inhibitors which utilizes the compounds.

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patent: 5110812 (1992-05-01), Han
patent: 5273982 (1993-12-01), Alig
Bajusz et al. "Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm," Chem. Abs. 99: 205609w, 1983.
Glusa et al. "The influence of benzamidine derivaties on human platelet function," Thrombosis et Diathesis Haemorrhagica 31: 172-178, 1974.
Fareed et al., Ann. N.Y. Acad. Sci. 370: 765-784, 1981.

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