Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-08-09
2011-08-09
Carlson, Karen (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S320100, C435S325000, C530S300000, C536S023100
Reexamination Certificate
active
07993848
ABSTRACT:
A TNF-α binding polypeptide is provided, which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are also provided. Also provided are methods comprising a step of affinity separation or detection, in which step a polypeptide according to the invention is used. Such methods may be used for reducing the content of TNF-α in a body fluid.
REFERENCES:
patent: WO 03/080655 (2003-10-01), None
patent: WO 2005/003156 (2005-01-01), None
patent: WO 2005/075507 (2005-08-01), None
López-Moratalla, Natalia, et al., “Immunomodulation induced by synthetic peptides derived from Staphylococcus aureus protein A”, Elsevier Science B.V., Biochimica et Biophysica Acta, vol. 1221, pp. 153-158, XP-002409247 (1994).
Nord, Karin, et al., “A Combinatorial library of an α-helical bacterial receptor domain”, Protein Engineering, vol. 8, No. 6, pp. 601-608, XP-002190390 (1995).
Sinha, Pratima and Ray, Prasanta K., “Functional Dichotomy of a 20-Mer and 16-Mer Peptide Derived From Staphylococcus aureus Protein A: Importance of Aminoacid Sequence”, Immunopharmacology and Immunotoxicology, vol. 24, No. 2, pp. 199-210 XP-008071866 (2002).
Affibody AB
Carlson Karen
Garabedian Todd E.
Wiggin and Dana LLP
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